Segregation: Flammables and oxidizers, poison inhalation hazards, corrosives, and other types of hazards must be separated. The most common segregation that gas distributors must employ is for flammables and oxidizers. The regulations state that flammables and oxidizers must be separated by a 20-ft or a 5-ft 1/2 hour rated firewall. Remember the fire triangle: if you have fuel (flammable gas) and a source of oxygen (oxidizing gas), then all you need is heat/source of ignition, and you will have a fire or explosion at your facility.
Securement: Compressed gas manufacturers and distributors are allowed to NEST cylinders if they choose for cylinder securement. All other industries must use chains, straps, or otherwise secure cylinders for compliance. An unsecured cylinder is heavy and may have devasting consequences if ruptured.